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Faculty James M. Bower, Ph.D. Research Imaging Center Cajal Neuroscience Research Center Lab page: http://bower-lab.org Research Interests The research of Dr. Bower and his students involves the general relationship between structure and function in neural circuits. Organized around anatomically and physiologically accurate computer models of systems, circuits, neurons, and subcellular components, work in the laboratory involves both the olfactory system, cerebellum, and related circuits. In addition to modeling, research projects involve a wide range of anatomical, physiological, and behavioral techniques, including: electron and light microscopy, intracellular and extracellular recording in vivo and in vitro, multi-single unit recording in anesthetized and behaving animals, behavioral testing in both laboratory animals and humans, and human and animal imaging (PET, fMRI). Recent Publications Amir Madany Mamloukm, A., Chee-Ruiter, C., Hofmann, U.G., and Bower, J.M. (2003) Mapping olfactory perception space by using multidimensional scaling and self-organizing maps. Neurocomputing 52-54: 591-597. Bower, J.M. and Parsons, L. (2003) Rethinking the Lesser Brain, Scientific American 289: 50-57. Fontanini, A., Spano, P.F., and Bower, J.M. (2003) Ketamine/xylazine induced slow (<1.5 Hz) oscillations in the rat piriform (olfactory) cortex are functionally correlated with respiration J. Neurosci. 23: 7993-8001. Bower, J.M. (2002) The functional organization of cerebellar circuitry reconsidered. In: Highstein, Stephen M, and Thach, Tomas. W. eds), The Cerebellum: Recent Developments in Cerebellar Research. Annals of the New York Academy of Sciences. Vol. 978 pp. 135-155. Brown, I.E., and Bower, J.M. (2002) The influence of somatosensory cortex on climbing fiber responses in the rat cerebellum following peripheral tactile stimulation. J Neurosci. 22(15): 6819-6829. Hucka, M., Shankar, K., Beeman, D., Bower, J.M. (2002) The modeler's workspace: Making model-based studies of the nervous system more accessible. In: Computational Neuroanatomy: Principles and Methods (G.A. Ascoli, Ed.) Humana Press, Totowa, New Jersey pp: 83-103. Santamaria F, Jaeger D, De Schutter E, Bower JM. (2002) Modulatory effects of parallel fiber and molecular layer interneuron synaptic activity on purkinje cell responses to ascending segment input: a modeling study. J Comput Neurosci. 13:217-235. Bower, J.M., and Bolouri. H. (2001) Computational Modeling of Genetic and Biochemical Networks MIT Press.
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