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Faculty
Biography Joe L. Martinez, Jr. earned a B.A. in Psychology from the University of San Diego in 1966, an M.S. in Psychology from New Mexico Highlands University in 1968 and completed a Ph.D. at the University of Delaware in 1971 with a specialization in Physiological Psychology. He served for 13 years as a Professor in the Department of Psychology at the University of California, Berkeley. Currently, he is the Ewing Halsell Distinguished Chair and Director of the Cajal Neuroscience Institute at the University of Texas at San Antonio, the Co-director of the San Antonio Life Sciences Institute, and the director of the Summer Program in Neuroscience, Ethics, and Survival (SPINES) at the Marine Biological Laboratory in Woods Hole, MA. Dr. Martinez is also an Associate Editor for the American Psychologist and serves on the Editorial Board of Behavioral Neuroscience. Dr. Martinez has been recognized by several organizations for his outstanding contribution to student development. He received the Raza Recognition Award in 1986, the American Association for the Advancement of Science Mentor Award for Lifetime Achievement in 1994, the National Hispanic Science Network on Drug Abuse Outstanding Mentorship Award in 2001, and the Association of Neuroscience Departments and Programs Education Award in 2003. Current Research Interests His laboratory’s research interests lie in the neurobiology of learning and memory, and the laboratory uses a variety of techniques to examine the mechanisms that underlie these memory processes in the mammalian brain. Currently, he uses DNA microarray technology to investigate candidate genes involved in Long Term Potentiation (LTP), a cellular model of learning and memory, and drug abuse and addiction. In addition, he uses confocal microscopy to determine the degree to which radiation exposure affects hippocampal morphology, and how these structural alterations impact animals’ behavior on hippocampus-dependent tasks such as trace fear conditioning and the Morris Water Maze. Laboratory Personnel Angela Sikorski, Ph.D., Postdoctoral Research Scholar Graduate Students James Orfila, M.S. Recent Publications (2000 – present) Derrick, B. E., A. D. York, and J. L. Martinez. Increased granule cell neurogenesis in the adult dentate gyrus following mossy fiber stimulation sufficient to induce long-term potentiation. Brain Research 857: 300-7, 2000. Barea-Rodríguez, E. J., D. T. Rivera, D. B. Jaffe, and J. L. Martinez, Jr. Protein synthesis inhibition blocks the induction of mossy fiber long-term potentiation in vivo. Journal of Neuroscience, 2000, 8528-8532. Hernandez, R. V., Garza, J.M., Graves, M., Martinez, Jr., J.L. LeBaron, R.G. The process of reducing CA1 long-term potentiation by the integrin binding peptide GRGDSP occurs within the first few minutes following theta burst stimulation. Biological Bulletin, 2001, 201, 236-237. Martinez, C.O., Do, V.H., Martinez, Jr., J.L., and Derrick, B.E. Associative long-term potentiation (LTP) among extrinsic afferents of the hippocampal CA3 region in vivo. Brain Research, 2002, 940, 86-94. Viet, V. Do, Martinez, C.O., Martinez, Jr., J.L., and Derrick, B.D. Long-term potentiation in the direct perforant path projections to the hippocampal CA3 regions in vivo. Journal of Neurophysiology, 2002, 87, 669-678. Peng, H., Derrick, B.E., and Martinez, Jr., J.L. Identification of up-regulated SCG 10 mRNA expression associated with late-phase LTP in rat hippocampal Schaffer-CA1 pathway in vivo. Journal of Neuroscience, 2003, 23, 6617-6626. Thompson, K.J., Orfila, J.E., Achanta, P., Martinez Jr., J.L., Gene expression associated with in vivo induction of early phase long-term potentiation (LTP) in the hippocampal mossy fiber cornus ammonis (CA)3 pathway. Cellular and Molecular Biology, 49(8), 1281-1287, 2003. LeBaron, R.G., Hernandez, R.V., Orfila, J.E., and Martinez, Jr., J.L. An integrin binding peptide reduces hippocampal long-term potentiation during the first few minutes following theta burst. Neuroscience Letters, 2003, 339, 199-202. Cao, Z., McAdory, B.S., Wang, Y., Peng, H., Martinez, J.L., Jr., and Townsel, J.G. The chemorepellant semaphorin is expressed in the horseshoe crab, Limulus Polyphemus. Journal of Cellular and Molecular Biology, 2003, 49, 1261-1267. Thompson, K.J., Orfila, J.E., Achanta, P., and Martinez, Jr., J.L. Gene expression associated with in vivo induction of early phase-LTP in the hippocampal mossy fiber–CA3 pathway. Journal of Cellular and Molecular Biology, 2003, 49, 1281-1287. Peng, H., Derrick, B.E. & J.L. Martinez, Jr. Time-course study of SCG10 mRNA levels associated with LTP induction and maintenance in the rat Schaffer-CA1 pathway in vivo. Brain Research: Molecular Brain Research, 120 (2), 182-187, 2004. Meilandt, W.J., Barea-Rodriguez, Harvey, S.A., and Martinez, Jr., J.L. The role of hippocampal CA3 opioid receptors in spatial learning and memory. Journal of Neuroscience, 2004, 24, 2953-2962. LeBaron, R.G., Hernandez, R.V., Navarro, M., and Martinez, Jr. A Focal Adhesion-Like Process Underlies Induction of Long-Term Potentiation in the Schaffer Collateral-CA1 Region of the Hippocampus. Neuron Glia Biology, 2005, 1, 1-9. Thompson, K.J., Mata, M., Orfila, J.E., Barea-Rodriguez, E.J., and Martinez, J.L., Jr. The metabotropic glutamate receptor antagonist AIDA blocks induction of mossy fiber-CA3 LTP in vivo. Journal of Neurophysiology, 2005, 93, 2668-2673.
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Joe L. Martinez Jr., Ph.D.
