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Non-Tenure Faculty
M.D., Baku Medical Institute, Baku, Azerbaijan (former USSR) Ph.D., Cardiovascular Biology and Pathology, Moscow State University and Ivanovo Medical Institute, Ivanovo, Russia (former USSR); Institute of Human Morphology, Russian Academy of Medical Sciences, and Russian Cardiology Center, Moscow, Russia (former USSR) Research Fellow,
Department of Anatomy and Developmental Biology, University Research Fellow, The Cleveland Clinic Foundation, Cleveland, Ohio, USA Dr. Aliev joined the UTSA faculty in 2006 from Case Western Reserve University as Assistant Professor of Pathology and co-Director of the Microscopy Research Center. He is a member of several editorial boards including Microscopy Research and Techniques, Journal of Cellular and Molecular Medicine, Neurotoxicity Research, Histology & Histopathology, American Journal of Alzheimer’s Disease and Other Dementia. He also serves as Editor for Central European Journal of Biology (Neuroscience Section). Research Interests Our research focuses on the cellular and subcellular mechanisms of pyramidal neuronal and vascular wall cell damage during the development of Alzheimer’s diseases (AD) and the future new wave of treatments for this devastating disease. We have shown the ultrastructural and molecular mechanisms of the features in the changes on mitochondria (DNA deletion, Cytochrome C Oxidase activity, and redox activity (Fe)), protein modification and oxidation (HNE) and RNA (8OHG) oxidation during normal aging (in a dog model of aging), stroke (cardiac arrest and resuscitation), and in transgenic mouse models of AD and human AD by using in situ hybridization and immunocytochemistry techniques at the light and electron microscopic levels. Selective mitochondrial antioxidant (e.g., lipoic acid and l-carnitine) will also be tested in different experimental models for future application in future clinical trials of these compounds as an alternative prophylactic and treatment strategy for neurodegeneration, cardio- and cerebrovascular diseases. The biochemical properties of these protein activities are also of interest in our ongoing research. Recent Publications Aliev G, Smith MA, Obrenovich ME, de la Torre JC, Perry G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotoxicity Res 5:491-504, 2003. Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avila J, Jones PK, Castellani RJ, Smith MA, Perry G. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol 162:1623-1627, 2003. Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G. Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain Pathol 13:630-638, 2004. de la Torre JC, Aliev G, Perry G. Drug therapy in Alzheimer’s disease. New Eng J Med 351:1911-1913, 2004. Zhu X, Smith MA, Perry G, Aliev G. Mitochondrial failure in Alzheimer disease. Am J Alz Dis Other Dement 19:345-352, 2004. Aliev G, Smith MA, de la Torre JC, Perry G. Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion 4:649-663, 2004. Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurol Res 26:547-53, 2004. Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA. Pathobiology of familial hypercholesterolemic atherosclerosis. J Submicrosc Cytol Pathol 36:225-240, 2004. Moreira PI, Siedlak SL, Aliev G, Zhu X, Cash AD, Smith MA, Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. J Neural Transm 112:921-932, 2005. Aliev G, Obrenovich ME, Seyidova D, de la Torre JC. Exploring ischemia-induced vascular lesions and potential pharmacological intervention strategies. Histol Histopathol 20: 261-273, 2005. Bragin V, Chemodanova M, Dzhafarova N, Bragin I, Czerniawski JL, Aliev G. Integrated treatment approach improves cognitive function in demented and clinically depressed patients. Am J Alz Dis Other Dement 20:21-26, 2005. Liu Q, Smith MA, Avilá J, De Bernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PLR, Sayre LM, Perry G. Alzheimer-specific epitopes of tau represent lipid peroxidation induced conformations. Free Radic Biol Med 38:746-754, 2005. Aliyev A, Chen S, Seyidova D, Smith MA, de la Torre JC, Aliev G. Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease. J Neurol Sci 229-230:285-292, 2005. de la Torre JC, Aliev G. Inhibition of vascular nitric oxide after rat chronic brain ischemia: Spatial memory and immunocytochemical changes. J Cerebral Blood Flow Metab 25:663-672, 2005. Obrenovich M.E., Smith MA., Siedlak SL., Chen S., de la Torre JC., Perry G. and Aliev G. Overexpression of GRK2 in Alzheimer’s disease and in a Chronic Hypoperfusion Rodent Model is an Early Marker of Brain Mitochondrial Lesions. Neurotoxicity Res 10:43-56, 2006. Aliev G, Samedov SKH, Obrenovich ME, Mironov AA, Burnstock G, LaManna JC, Smith MA, Perry G, Gasimov EK. Molecular features of the development of atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits. The Reports of the National Academy of Sciences of the Azerbaijan Republic, 2006, No 2:57-66. Aliev G., Miller J.P., Leifer D.W., Obrenovich M.E., Shenk J.C., Smith M.A., LaManna J.C., Perry G., Lust W.D., and Cohen A.R. Ultrastructural analysis of a murine models of congenital hydrocephalus produced by overexpression of transforming growth factor-β1 in the central nervous system. J. Submicr. Cytology & Pathol. 2006; 38(2-3)85-91. Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PLR, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. J Neurol Sci, 2007; 257:240-246. Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Zhu X, Smith MA, Perry G. Mitochondrial autophagocytosis in Alzheimer disease. In: Proceedings of the 10th International Conference on Alzheimer’s Disease and Related Disorders, Medimond S.R.l., Bologna, in Alzheimer’s Disease: New Advances, Iqbal K, Winblad B, Avila J, Eds, Medimond S.R.l., Bologna, Italy, 2006, pp 373-376. Moreira P. I, Nunomura A., Honda K., Aliev G., Casadesus G., Zhu X., Smith M.A., and Perry G. The key role of oxidative stress in Alzheimer disease. In: "Oxidative Stress and Neurological Disorders." G.A. Qureshi, Parvez SH, Eds, Elsevier B.V., Amsterdam, 2007, pp 267-282. Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathology & Exper. Neurology, 2007, 66(6):525-532. Erratum in: J Neuropathol Exp Neurol. 2007 Jul;66(7):674. Moreira PI, Siedlak SL, Wang X., Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 2007 Nov-Dec; 3(6):614-5. Epub 2007 Aug 14. Klionsky D.J., Abeliovich H., Agostinis P., Agrawal D.K., Aliev G., Askew D.S. et al., Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008, 4-2, 1-25. Epub 16 February, 2008. Shenk JC, Aliev G, Moreira PI , Nunomura A, Zhu X , Smith MA, Perry G. Antioxidant Therapy in Alzheimer Disease: Theory and Practice. Drug Metabolism Letters 2007, in press. Aliev G, J. Liu, K. Xu, M. Puchowicz, S.L. Siedlak, J.C. Shenk, M.A. Smith, E. Gasimov, M.E. Obrenovich, K. Fischbach, J. Koistinaho, J.C. LaManna, B.N. Ames and Perry G. ApoE4 in mice induces age-dependent brain hypoperfusion, neuronal, glial and microvascular damage, and cognitive impairment, which can be prevented by feeding Acetyl-L-Carnitine and R-Lipoic Acid. Proceeding AD/PD Conference 2007. Monduzzi Editore, Bologna, Italy. 2007 in Press. Moreira P., Nunomura A., Takeda A., Shenk J.C., Aliev G., Smith M.A. and Perry G. Nucleic Acid Oxidation in Alzheimer disease. Free Radical Biology and Medicine. 2007/2008 in press. Aliev G., Gasimov E. Obrenovich M.E, Fischbach K., Shenk J.C., Smith M.A. and Perry G. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer’s disease. Vascular Health and Risk Management (VHRM), 2007/2008, in press.
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Gjumrakch
Aliev, M.D., Ph.D.